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Clinical Pro – advanced skincare for visible results and skin comfort
Yellow Rose Clinical Pro is a professional skincare range for visible signs of aging, uneven skin tone, loss of elasticity, and a skin barrier in need of extra support. The range combines modern cosmetic technology with PDRN, phyto-PDRN, exosomes, biomimetic peptides, retinoids, ceramides, hyaluronic acid, niacinamide, and tranexamic acid.
Clinical Pro includes five products with clear functions: daily anti-aging care, progressive retinoid care, and soothing and barrier-supporting care before and after professional treatments. The products can be used individually or combined in a routine tailored to the skin's current condition and tolerance.
What is Yellow Rose Clinical Pro?
Clinical Pro is developed for professional skincare protocols and targeted home care between treatments. The range focuses on three main areas:
- Anti-aging and radiance: care for fine lines, reduced elasticity, dullness, and uneven skin tone.
- Texture and pigmentation: progressive evening care with retinal and HPR for a smoother, clearer, and more balanced skin appearance.
- Barrier and comfort: soothing and moisturizing care for dry, sensitive, or temporarily reactive skin, as well as skin before and after aesthetic treatments.
Not all products are intended for simultaneous use. When the skin barrier is stressed, the focus should be on hydration, comfort, and protection. Retin-Ax is introduced only when the skin feels stable and is used according to a gradual step-up program.
Who is Clinical Pro suitable for?
- mature skin with visible lines or reduced firmness;
- dull skin lacking radiance;
- uneven skin tone and visible pigmentation changes;
- uneven skin texture, visible pores, or excess sebum;
- dry and dehydrated skin that feels tight;
- sensitive or temporarily reactive skin in need of barrier support;
- skin prepared for or cared for after a professional aesthetic treatment.
The choice should always be based on the skin's condition. The PDRN products are suitable for a daily routine for skin quality, moisture, and radiance. Retin-Ax is an active evening product that requires gradual acclimatization. Post Care Soothing HydroGel and Repair Cream are the range's soothing and barrier-supporting options.
Which Clinical Pro product should you choose?
PDRN & Exosomes BioSerum – for radiance, elasticity, and smoother texture
Yellow Rose Clinical Pro PDRN & Exosomes BioSerum 30 ml is a lightweight anti-aging serum for mature, dull, or less firm skin.
The formula combines plant-based phyto-PDRN with Centella and Goji exosomes, peptides, niacinamide, tranexamic acid, ceramides, hyaluronic acid in multiple molecular weights, vegan collagen fragments, adenosine, and beta-glucans.
The serum helps the skin feel more hydrated, soft, and elastic. With regular use, the skin surface can appear smoother, and the skin tone can achieve a clearer and more radiant look. The fast-absorbing texture is used morning and evening under face cream.
- 96% ingredients of natural origin according to ISO 16128.
- Suitable for vegans.
- Dermatologically tested.
PDRN Advanced Cream – daily anti-aging care with Salmon PDRN
Yellow Rose Clinical Pro PDRN Advanced Cream 50 ml is a light hydrogel cream for fine lines, reduced firmness, dullness, and uneven skin tone.
The cream contains 2000 ppm, equivalent to 0.2%, highly purified PDRN of salmon origin. The formula is supplemented with Centella exosomes, a multi-peptide complex, plant stem cells, niacinamide, tranexamic acid, ceramides, hyaluronic acid in multiple molecular weights, vegan collagen fragments, adenosine, beta-glucans, and resveratrol.
It provides long-lasting hydration and helps the skin feel softer, smoother, and more comfortable. The cream can be used morning and evening on cleansed skin, alone or after BioSerum. After a professional treatment, it should only be used when the skin barrier is intact and according to the therapist's recommendation.
- 97% ingredients of natural origin according to ISO 16128.
- Fast-absorbing finish without a heavy or greasy feel.
- Dermatologically tested.
- Contains PDRN of salmon origin and is therefore not vegan.
Retin-Ax Cream – progressive evening care with retinal and HPR
Yellow Rose Clinical Pro Retin-Ax Cream 30 ml combines two modern retinoids: retinal and Hydroxypinacolone Retinoate, HPR. The product is developed for visible lines, uneven skin texture, pigmentation, reduced firmness, and excess sebum.
Retin-Ax is available in three levels:
- 0.1% Starter: 0.05% retinal + 0.05% HPR. For first-time users and early visible signs of aging.
- 0.14% Moderate: 0.07% retinal + 0.07% HPR. For skin that already has some retinoid tolerance and wants to actively address lines, skin tone, and nascent loss of firmness.
- 0.2% Advanced: 0.1% retinal + 0.1% HPR. For experienced retinoid users with more prominent signs of photoaging or uneven pigmentation.
Start with the lowest suitable level 2–3 evenings a week. Gradually increase frequency according to skin tolerance. Only move to the next level when the skin tolerates the current product with regular evening use for at least 4–8 weeks.
Retin-Ax is for evening use only. Avoid use immediately before or after invasive or skin-resurfacing treatments and maintain an interval of at least 10 days. Always complete your morning routine with a broad-spectrum sunscreen.
Post Care Soothing HydroGel – immediate cooling comfort
Yellow Rose Clinical Pro Post Care Soothing HydroGel 125 ml is a light and cooling hydrogel for sensitive, irritated, or temporarily reactive skin.
The formula contains phyto-PDRN, Centella exosomes, soothing peptides, adenosine, hyaluronic acid in two molecular weights, vegan collagen fragments, beta-glucans, panthenol, ceramides, and exopolysaccharides.
The hydrogel is developed for use immediately after aesthetic treatments and can then be applied at home 1–2 times a day as needed. It can also be used as a hydrating overnight mask. Exact usage after treatments such as peeling, microneedling, laser, IPL, HIFU, RF, or injection treatments should follow the therapist's instructions.
- 92% ingredients of natural origin according to ISO 16128.
- Suitable for vegans.
- Dermatologically tested on sensitive skin.
Repair Cream – barrier support before and after treatment
Yellow Rose Clinical Pro Repair Cream 50 ml is a soothing and moisturizing hydrogel cream for sensitive skin and a temporarily weakened skin barrier.
The formula combines phyto-PDRN, Centella exosomes, peptides, colloidal oatmeal with beta-glucans, hyaluronic acid in multiple molecular weights, and ceramides. The cream helps the skin retain moisture and reduces feelings of dryness, tightness, and discomfort.
Repair Cream can be used morning and evening after a treatment. It can also be introduced 1–3 weeks before a planned aesthetic treatment to provide the skin with more moisture, comfort, and barrier support. Always tailor pre- and post-care according to the therapist's instructions.
- 90% ingredients of natural origin according to ISO 16128.
- Suitable for vegans.
- Dermatologically tested on sensitive skin.
How to build a Clinical Pro routine
Daily routine for mature or dull skin
Morning:
- Cleanse skin gently.
- Apply PDRN & Exosomes BioSerum.
- Follow with PDRN Advanced Cream.
- Finish with broad-spectrum sunscreen.
Evening:
- Remove makeup, sunscreen, and daily impurities.
- Apply PDRN & Exosomes BioSerum.
- Finish with PDRN Advanced Cream.
Step-up routine with Retin-Ax
- Cleanse skin and let it dry.
- Apply a small amount of Retin-Ax in the evening.
- Avoid eye contour, lips, and irritated skin areas.
- Follow with PDRN Advanced Cream or Repair Cream for extra comfort if needed.
- Use sunscreen every morning.
Start 2–3 evenings a week and increase only if the skin remains comfortable. Use BioSerum and PDRN Advanced Cream on other evenings. Do not combine multiple retinoid products in the same routine and adjust the use of acids and peels according to skin tolerance.
Soothing routine after professional treatment
- Follow the therapist's instructions for cleansing the area.
- Apply Post Care Soothing HydroGel and let it absorb without intense massage.
- Follow with Repair Cream.
- Apply recommended sunscreen during the day when appropriate for the specific treatment.
In clinic, Post Care Soothing HydroGel can be used as a 20-minute application and then followed by Repair Cream. At home, the hydrogel can be used 1–2 times a day as needed.
Key ingredients in Clinical Pro
- Salmon PDRN: PDRN Advanced Cream contains 2000 ppm highly purified PDRN of salmon origin. In cosmetic skincare, the ingredient is used in formulations focusing on moisture, elasticity, and a smoother, more well-maintained skin appearance.
- Phyto-PDRN: a plant-based PDRN from Camellia japonica used in BioSerum, Retin-Ax, Post Care HydroGel, and Repair Cream.
- Centella and Goji exosomes: biotechnologically produced cosmetic ingredients that complement care for skin comfort, barrier feel, smoother texture, and a more balanced skin appearance. Goji exosomes are included in BioSerum.
- Biomimetic peptides: complement the range's anti-aging and barrier-focused formulations and contribute to a smoother and more well-maintained skin feel.
- Retinal and HPR: two retinoids in Retin-Ax used for evening care focusing on lines, texture, pigmentation, and sebum balance.
- Ceramides: help maintain skin's moisture and comfort and complement the skin's natural barrier lipids.
- Hyaluronic acid: binds moisture and helps the skin feel softer, smoother, and more hydrated.
- Niacinamide and tranexamic acid: contribute to a clearer and more even skin appearance.
- Beta-glucans, colloidal oatmeal, and panthenol: used in the range's soothing and barrier-supporting formulations to provide more comfort when the skin feels dry or reactive.
Documented results from product tests
Several Clinical Pro products have been evaluated with instrumental and functional tests under dermatological control. The results below apply to the specific product tested, the period of use, and the test conditions. Individual results may vary.
PDRN & Exosomes BioSerum after 28 days
- 22% reduction in the number of visible wrinkles.
- 13% reduction in wrinkle area.
- 11% reduction in wrinkle volume.
- 8% increase in measured skin density.
- 14% improved elasticity.
- 6% improved firmness.
- 91% of participants had a measurable improvement in skin radiance.
- All participants had measurable improvement in hydration and reduced TEWL.
Retin-Ax Cream 0.14% after 28 days
- 12% reduction in the number of visible wrinkles.
- 5% reduction in wrinkle area.
- 9% reduction in wrinkle volume.
- 4% reduction in measured wrinkle depth and length.
- 10% improved elasticity.
- 7% improved firmness.
- 20% reduction in measured melanin level.
- 20% reduction in sebum production.
The results for Retin-Ax specifically apply to the 0.14% strength and should not be automatically transferred to 0.1% or 0.2%.
Post Care Soothing HydroGel – immediate results
- Soothing sensation recorded within 30 seconds.
- 19% reduction in transepidermal water loss, TEWL, after 15 minutes.
- 10% reduction in visible redness after 15 minutes.
- 27% improved hydration after 30 minutes.
Repair Cream
- 32% reduction in TEWL after 15 minutes.
- 18% reduction in visible redness after 15 minutes.
- 16% increase in measured skin density after 28 days.
- 9% reduction in the number of visible wrinkles after 28 days.
- 9% improved elasticity after 28 days.
- 4% improved firmness after 28 days.
For PDRN Advanced Cream, no complete clinical efficacy results are yet stated in the producer's Clinical Pro presentation. Therefore, we describe the cream based on its formulation, area of use, and skin feel, and do not attribute the results from BioSerum or other products to it.
Good to know
- BioSerum, Retin-Ax, Post Care Soothing HydroGel, and Repair Cream contain plant-based phyto-PDRN.
- PDRN Advanced Cream contains PDRN of salmon origin and is not vegan.
- BioSerum, Post Care Soothing HydroGel, and Repair Cream are stated as vegan by the manufacturer.
- Retin-Ax is for evening use only and is introduced 2–3 times a week.
- Maintain at least a 10-day interval between Retin-Ax and invasive or skin-resurfacing treatments.
- Sunscreen should be used every morning, especially when using retinoids and in connection with aesthetic treatments.
- Do not use active products on damaged or severely irritated skin.
- Discontinue use and consult a skin therapist or healthcare provider if irritation becomes severe or persistent.
- Aftercare should always be adapted to the type of treatment and the instructions of the responsible therapist.
Victoria's professional advice
The most important thing with Clinical Pro is to choose according to your skin's condition and not try to use all active ingredients at once. For mature or dull skin, I recommend starting with BioSerum and PDRN Advanced Cream. This provides a stable daily routine focusing on moisture, elasticity, comfort, and radiance.
If you want to add Retin-Ax, your skin should first feel balanced. Start with a suitable low level 2–3 evenings a week and give your skin at least 4–8 weeks before considering increasing the strength. A higher concentration is not automatically better – a consistent routine that your skin tolerates provides better conditions for a good result.
After a professional treatment, the skin typically needs calm, moisture, and barrier support. In that case, Post Care Soothing HydroGel and Repair Cream are more suitable than retinoids and exfoliating products. Always follow the personalized aftercare plan you have received.
Frequently asked questions about Clinical Pro
What is the difference between BioSerum and PDRN Advanced Cream?
BioSerum is a light serum with plant-based phyto-PDRN and Centella and Goji exosomes. It is applied before face cream. PDRN Advanced Cream is a daily hydrogel cream with 2000 ppm PDRN of salmon origin, Centella exosomes, peptides, ceramides, and hydrating ingredients.
Can BioSerum and PDRN Advanced Cream be used together?
Yes. Apply BioSerum first and follow with PDRN Advanced Cream. In the morning, the routine is finished with sunscreen.
Which Retin-Ax strength should I start with?
If you are a beginner, 0.1% Starter is the lowest level. Start 2–3 evenings a week and gradually increase. Only move to a higher level after at least 4–8 weeks and only if the skin tolerates regular use well.
Can I combine Retin-Ax with PDRN products?
Yes. BioSerum can be used in the morning or on evenings without Retin-Ax. After Retin-Ax, PDRN Advanced Cream or Repair Cream can be used if needed for extra comfort. Start simply and do not add several new active products at the same time.
How long should I pause Retin-Ax before and after a treatment?
The manufacturer specifies at least a 10-day interval before and after invasive or skin-resurfacing treatments. Your therapist may recommend a longer pause depending on the treatment and your skin's condition.
Which products are suitable after microneedling, peeling, or laser?
Post Care Soothing HydroGel and Repair Cream are the range's products for soothing, hydrating, and barrier-supporting aftercare. The exact start time and frequency of use should be adjusted according to the treatment and follow the therapist's instructions.
Can Repair Cream be used before a treatment?
Yes. According to the manufacturer, Repair Cream can be used morning and evening for 1–3 weeks before a planned treatment to provide the skin with more moisture, comfort, and barrier support.
Are all Clinical Pro products vegan?
No. PDRN Advanced Cream contains PDRN of salmon origin. BioSerum, Post Care Soothing HydroGel, and Repair Cream are stated as vegan by the manufacturer.
Do I need to use sunscreen?
Yes. Use a broad-spectrum sunscreen as the last step every morning. It is especially important when using Retin-Ax, working with pigmentation, or following a routine before or after an aesthetic treatment.
Explore more skincare based on skin needs
If you wish to complement your routine, you can explore our face serums, face creams, products for mature skin, and skincare for dry skin. Finish your morning routine with a suitable sunscreen.